I fully agree Markham that we need a different model of disease. We have known for decades that increasing the levels of neurotransmitters does not treat anything. Changing the amount of transmission matters, as does how you do it. Like many things in medicine this helps in ways we do not understand. Also because a system responds in an expected way does not mean it should not get attention. A leg will understandably break when hit by a car. That is not a reason not to treat it. A step beyond allostasis is to look at Complex systems (not complicated systems), which behave according to nonlinear dynamics. You can spot them by gene-environment interactions, threshold effects, syndromes which exist on continuums, etc. There is much more detail involved.

All in all I applaud your work to move things foreward. But allostasis is too general to explain disease as different diseases have different types of paths.